Welcome to the Boland lab!
We are a friendly, focused and enthusiastic group working at the intersection of Structural Biology, Molecular Biology and Cell Biology. We leverage the latest developments in Structural Biology, and here in particular cryo-electron microscopy (cryo-EM) with complementary biophysical techniques (proteomics, light-microscopy, microfluidics, etc.), to adress complex biological questions in the field of cell cycle regulation and cell signaling.
HELMUT HORTEN FOUNDATION GRANT AWARDED (GPCR STRUCTURES)
Thank you very much to the Helmut Horten Foundation for funding our new project in collaboration with the Stoeber lab. We will (probably) announce a new postdoc position soon if you would like to join us in beautiful Switzerland. https://helmut-horten-stiftung.org/en/#
SNSF POSTDOCTORAL FELLOWSHIP AWARDED TO MARGHERITA
Congratulations to Margherita
to be awarded a SNSF postdoctoral fellowship (Marie Curie replacement scheme) for her research proposal on separase. Bravo!
WELCOME TO GENEVA LI!
Li Yao will join us as a PhD student. Li has recently been awarded a scholarship from the Chinese Scholarship Council (CSC) and we are very much looking forward to welcome her to our group in August '23.
A very warm welcome Li!
REVIEW HUMAN SEPARASE REGULATION
Our review on "The molecular mechanisms of human separase regulation" is now published at Biochemical Society Transactions.
We summarise recent structural and functional data on separase inhibition, and discuss new ideas how phosphorylation of separase and its substrates may control protease activity.
Please click the image for more information.
ILSE SCHAEFFNER HAS BEEN AWARDED A FULBRIGHT SCHOLARSHIP
Ilse Schaeffner will join our group as a Fulbright scholar in September this year. Currently, Ilse is working in the group of Prof. Michael J. Eck at Harvard Medical School. During her internship she will study proteins involved in cell division and cell signalling using cryoEM.
Congratulation Ilse on winning such a prestigious fellowship and we are looking forward to your start.
APC/C HIGH RESOLUTION STRUCTURES MANUSCRIPT NOW ONLINE
Our new work on APC/C regulation revealed by high resolution cryo-EM structures together with the groups of Leifu Chang and David Barford is now on BioRxiv. Congratulations to Anna Höfler, Jun Yu and all other authors. The manuscript can be found here:
Selected publications (Boland group)
Yu J, Morgan DO, Boland A.Biochem Soc Transactions. 2023 Jun 28
CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.
Spataro S, Guerra C, Cavalli A, Sgrignani J, Sleeman J, Poulain L, Boland A, Scapozza L, Moll S, Prunotto M.
FEBS Journal. 2022 Aug 23
Hepatic S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.
Ursino G, Ramadori G, Höfler A, Odouard S, Teixeira PS, Visentin F, Veyrat-Durebex C, Lucibello G, Firnkes R, Ricci S, Vianna CR, Jia L, Dirlewanger M, Klee P, Elmquist JK, Roth J, Vogl T, Schwitzgebel VM, Jornayvaz FR, Boland A, Coppari R.
Nature Communications. 2022 13(1):4107
Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.
Raia P, Yu J, Boland A.
Molecular & Cellular Oncology. 2021 Sep 24;8(4):1975473.
Structural basis of human separase regulation by securin and Cdk1-cyclin B1.
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A.
Nature. 2021 Aug;596(7870):138-142.
All our work is open access.
We would like to thank all our funding bodies for their trust and support. Merci!