Welcome to the Boland lab!

We are a friendly, focused and enthusiastic group working at the intersection of Structural Biology, Molecular Biology and Cell Biology. We leverage the latest developments in Structural Biology, and here in particular cryo-electron microscopy (cryo-EM) with complementary biophysical techniques (proteomics, light-microscopy, microfluidics, etc.), to adress complex biological questions in the field of cell cycle regulation and cell signaling.

LATEST NEWS

ANDREAS HAS BEEN SELECTED FOR THE EMBO YOUNG INVESTIGATOR PROGRAMME

November '22

Andreas has been selected as an EMBO Young Investigator alongside 23 other young PIs.
This network will provide unique opportunities for the exchange of ideas and to connect with researchers across Europe for all group members. Thank you EMBO!

SWISS ERC STARTING GRANT AWARDED

November '22

The Swiss National Science Foundation (SNSF) has awarded a "Swiss ERC Starting Grant" to our group.
We are very grateful for the past and future support. This really makes all the difference for our research on cell cycle control and membrane protein biology at the UNIGE.

SALUT MARGHERITA!

November '22

Finally Margherita joined our group and we are very exciting you are now with us. Margherita conducted her PhD in the group of Meindert H. Lamers in Leiden before moving to Geneva. Looking forward to more separase biology in future!

REVIEW ON DOCK-FAMILY GEFS PUBLISHED

October '22

Our review on the structure and cell signalling function(s) of DOCK-family GEFs has been published in FEBS letter.

REVIEW ON CEMIP PUBLISHED

August '22

In a collaborative effort Sofia Spataro published a review on the structure & function of CEMIP, with contributions from Lina Poulain! Congratulations to all authors.

WELCOME TO THE LAB XUEFENG!

August '22

We are very happy to have you as part of our lab and look forward to your start in September. Your expertise in GPCR purification will be a great asset to the group. We wish you great success!

RESEARCH PROJECTS

Our Current Focus

STRUCTURE AND FUNCTION OF CELL CYCLE REGULATORY PROTEINS

MEMBRANE PROTEIN BIOLOGY

UNDERSTANDING THE MOLECULAR BASIS OF METABOLIC PROTEIN CLUSTERS

GROUP PHOTO

from left to right:
Jun YU, Lina POULAIN, Anna HÖFLER, Sophia SCHMIDT, Andreas BOLAND, Yvan PFISTER, Margherita BOTTO, Xuefeng ZHANG (absent)

Details to each lab member

PUBLICATIONS

Selected publications (Boland group)

CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.
Spataro S, Guerra C, Cavalli A, Sgrignani J, Sleeman J, Poulain L, Boland A, Scapozza L, Moll S, Prunotto M.
FEBS Journal. 2022 Aug 23

Hepatic S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.
Ursino G, Ramadori G, Höfler A, Odouard S, Teixeira PS, Visentin F, Veyrat-Durebex C, Lucibello G, Firnkes R, Ricci S, Vianna CR, Jia L, Dirlewanger M, Klee P, Elmquist JK, Roth J, Vogl T, Schwitzgebel VM, Jornayvaz FR, Boland A, Coppari R.
Nature Communications. 2022 13(1):4107

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.
Raia P, Yu J, Boland A.
Molecular & Cellular Oncology. 2021 Sep 24;8(4):1975473.

Structural basis of human separase regulation by securin and Cdk1-cyclin B1.
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A.
Nature. 2021 Aug;596(7870):138-142.

All our work is open access.