Welcome to the Boland lab!
We are a friendly, focused and enthusiastic group working at the intersection of Structural Biology, Molecular Biology and Cell Biology. We leverage the latest developments in Structural Biology, and here in particular cryo-electron microscopy (cryo-EM) with complementary biophysical techniques (proteomics, light-microscopy, microfluidics, etc.), to adress complex biological questions in the field of cell cycle regulation and cell signaling.
REVIEW HUMAN SEPARASE REGULATION
Our review on "The molecular mechanisms of human separase regulation" is now published at Biochemical Society Transactions.
We summarise recent structural and functional data on separase inhibition, and discuss new ideas how phosphorylation of separase and its substrates may control protease activity.
Please click the image for more information.
ILSE SCHAEFFNER HAS BEEN AWARDED A FULBRIGHT SCHOLARSHIP
Ilse Schaeffner will join our group as a Fulbright scholar in September this year. Currently, Ilse is working in the group of Prof. Michael J. Eck at Harvard Medical School. During her internship she will study proteins involved in cell division and cell signalling using cryoEM.
Congratulation Ilse on winning such a prestigious fellowship and we are looking forward to your start.
ANDREAS HAS BEEN SELECTED FOR THE EMBO YOUNG INVESTIGATOR PROGRAMME
Andreas has been selected as an EMBO Young Investigator alongside 23 other young PIs.
This network will provide unique opportunities for the exchange of ideas and to connect with researchers across Europe for all group members. Thank you EMBO!
SWISS ERC STARTING GRANT AWARDED
The Swiss National Science Foundation (SNSF) has awarded a "Swiss ERC Starting Grant" to our group.
We are very grateful for the past and future support. This really makes all the difference for our research on cell cycle control and membrane protein biology at the UNIGE.
Finally Margherita joined our group and we are very exciting you are now with us. Margherita conducted her PhD in the group of Meindert H. Lamers in Leiden before moving to Geneva. Looking forward to more separase biology in future!
REVIEW ON DOCK-FAMILY GEFS PUBLISHED
Our review on the structure and cell signalling function(s) of DOCK-family GEFs has been published in FEBS letter.
Selected publications (Boland group)
CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.
Spataro S, Guerra C, Cavalli A, Sgrignani J, Sleeman J, Poulain L, Boland A, Scapozza L, Moll S, Prunotto M.
FEBS Journal. 2022 Aug 23
Hepatic S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.
Ursino G, Ramadori G, Höfler A, Odouard S, Teixeira PS, Visentin F, Veyrat-Durebex C, Lucibello G, Firnkes R, Ricci S, Vianna CR, Jia L, Dirlewanger M, Klee P, Elmquist JK, Roth J, Vogl T, Schwitzgebel VM, Jornayvaz FR, Boland A, Coppari R.
Nature Communications. 2022 13(1):4107
Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.
Raia P, Yu J, Boland A.
Molecular & Cellular Oncology. 2021 Sep 24;8(4):1975473.
Structural basis of human separase regulation by securin and Cdk1-cyclin B1.
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A.
Nature. 2021 Aug;596(7870):138-142.
All our work is open access.
Department of Molecular and Cellular Biology (MOCEL)
30 Quai Ernest-Ansermet
1211 Geneva, Switzerland
+41 22 379 61 27
We would like to thank all our funding bodies for their trust and support. Merci!