Welcome to the Boland lab!
We are a friendly, focused and enthusiastic group working at the intersection of Structural Biology, Molecular Biology and Cell Biology. We leverage the latest developments in Structural Biology, and here in particular cryo-electron microscopy (cryo-EM) with complementary biophysical techniques (proteomics, light-microscopy, microfluidics, etc.), to adress complex biological questions.
Our main focus lies in the fields of cell cycle regulation (Mitosis) and cell signaling (GPCRs).
LATEST NEWS
June '24
OUR GROUP IN OCT'23
Our structure-function relationship study has been published in Nature Communications. Many congratulations to Jun Yu, Xuefeng Zhang from our group and Amit Kumar from the Stoeber group on this achievement. Please click me.
October '24
µOR-NbE complex structure published
EMBO Fellowship award for Elda!
Elda Bauda who works as a PostDoc jointly associated with the group of Robbie Loewith has been awarded an EMBO fellowship. Hearty congratulations Elda! We are very happy for you.
March '24
ANDREA SVORINIC WILL JOIN THE STOEBER/BOLAND LABS
Andrea Svorinic will join the laboratories of Prof. Miriam Stoeber and ours to work on membrane proteins targeted and regulated by nanobodies. We are very excited to see you coming to Geneva in March. A hearty welcome, Andrea!
Apr'24
PREPRINT CYCLIN B1 PHOSPHATE-BINDING POCKET
In our first collaboration with the labs of Thomas Mayer, Florian Stengel (both University of Konstanz) and Tanja Bange (LMU Munich) we show that that a positively charged pocket in cyclin B1, and binds phosphorylated serine- or threonine-residues, is essential for correct execution of mitosis
PUBLICATIONS
Selected publications (Boland group)
Positively charged specificity site in cyclin B1 is essential for mitotic fidelity. Heinzle C, Höfler A, Yu J, Heid P, Kremer N, Stengel F, Bange T, , Boland A and Mayer TU. Research Square.
Structural Basis of μ-Opioid Receptor-Targeting by a Nanobody Antagonist. Yu J*, Kumar A, Zhang X, Martin C, Raia P, Kohl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A and Stoeber M. Nature Communications. 2024 15(1):8687, and bioRxiv.
New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C:CDH1:EMI1 complex. Höfler A, Yu J, Yang J, Zhang Z, Chang L, Grime GW, Garman EF, Boland A and Barford D. Nature Communications. 2024, and bioRxiv.
The molecular mechanisms of human separase regulation.
Yu J, Morgan DO, Boland A.Biochem Soc Transactions. 2023 Jun 28
CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.
Spataro S, Guerra C, Cavalli A, Sgrignani J, Sleeman J, Poulain L, Boland A, Scapozza L, Moll S, Prunotto M.
FEBS Journal. 2022 Aug 23
Hepatic S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.
Ursino G, Ramadori G, Höfler A, Odouard S, Teixeira PS, Visentin F, Veyrat-Durebex C, Lucibello G, Firnkes R, Ricci S, Vianna CR, Jia L, Dirlewanger M, Klee P, Elmquist JK, Roth J, Vogl T, Schwitzgebel VM, Jornayvaz FR, Boland A, Coppari R.
Nature Communications. 2022 13(1):4107
Structural basis of human separase regulation by securin and Cdk1-cyclin B1.
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A.
Nature. 2021 Aug;596(7870):138-142.
All our work is open access.
CONTACT US
Boland laboratory
Department of Molecular and Cellular Biology (MOCEL)
Sciences III
30 Quai Ernest-Ansermet
1211 Geneva, Switzerland
+41 22 379 61 27
FUNDING
We would like to thank all our funding bodies for their trust and support. Merci!